Cubs vs. Padres Prediction, Odds, Picks - April 16

Data Skrive

Seiya Suzuki and the Chicago Cubs will square off against Fernando Tatis Jr. and the San Diego Padres at PETCO Park on Wednesday at 4:10 p.m. ET, in the second game of a three-game series. Bookmakers list the Cubs as -154 favorites on the moneyline, while giving the underdog Padres +129 moneyline odds to win. Chicago (-1.5) is favored on the run line. The over/under is 8.5 runs for the game.

Here is everything you need to know from a betting perspective on the Cubs-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Shohei Ohtani scored 2 runs in the Los Angeles Dodgers’ Season Opener victory over the Chicago Cubs. Colin Cowherd discusses Ohtani’s dominance and how he will continue to transcend baseball.

Cubs vs. Padres Game Information & Odds

When: Wednesday, April 16, 2025 at 4:10 p.m. ET
Where: PETCO Park in San Diego, California
How to watch on TV: SDPA and MARQ

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Cubs -154 +129 8.5 -105 -115 -1.5 +110 -132

Cubs vs. Padres Prediction

Score Prediction: Padres 4, Cubs 3
Total Prediction: Under 8.5 runs
Win Probabilities: Cubs 54%, Padres 46%

Cubs vs. Padres Betting Insights

The Cubs have been favorites in eight games this season and won six (75%) of those contests.
This season Chicago has won two of its three games when favored by at least -154 on the moneyline.
Oddsmakers have implied with the moneyline set for this matchup that the Cubs have a 60.6% chance to win.
The Padres have been chosen as underdogs in six games this year and have walked away with the win four times (66.7%) in those games.
San Diego has played as an underdog of +129 or more just one time this year and came away with a loss in that game.
The moneyline set for this matchup implies the Padres have a 43.7% chance of walking away with the win.

Cubs Recent Betting Performance

The Cubs went 4-2 across the six games they were favored on the moneyline in their last 10 matchups.
Over their last 10 matchups (all had set totals), the Cubs combined with their opponents to hit the over on the run total seven times.
The Cubs have put together a 6-4-0 record against the spread over their past 10 games.

Cubs Recent Stats

Stat Avg/Total Record 6-4 Runs Per Game 6.0 HR 12 ERA 3.68 K/9 8.3

Cubs Player Insights

Kyle Tucker paces the Cubs with five home runs and 18 runs batted in.
Tucker ranks 11th in homers and fourth in RBI among all hitters in the majors.
Carson Kelly is batting .417 with a double, a triple, four home runs and 11 walks.
Suzuki is batting .292 with two doubles, a triple, four home runs and 11 walks.
Michael Busch has a club-high .310 batting average.
Busch is riding a three-game hitting streak into this one. In his last five games he is hitting .381 with two doubles, three home runs, a walk and seven RBI.

Padres Recent Betting Performance

The Padres have played as underdogs in four of their past 10 games and won two of those contests.
In their last 10 games with a total, the Padres and their opponents have combined to hit the over six times.
The Padres have won six of their last 10 games against the spread.

Padres Recent Stats

Stat Avg/Total Record 7-3 Runs Per Game 4.7 HR 12 ERA 3.52 K/9 8.2

Padres Player Insights

Tatis leads the lineup with a batting average of .361, while pacing the Padres in home runs, with six and runs batted in with 12.
In all of the big leagues, Tatis is second in homers and 20th in RBI.
Tatis has collected a hit in four games in a row. During his last five outings he is hitting .316 with four home runs, two walks and five RBI.
Manny Machado has seven doubles, a home run and eight walks while batting .317.
Machado ranks 132nd in home runs and 138th in RBI among all hitters in the majors.
Luis Arraez is batting .282 with three doubles, two home runs and two walks.
Xander Bogaerts is hitting .288 with five doubles and nine walks.

Shohei Ohtani scored 2 runs in the Los Angeles Dodgers’ Season Opener victory over the Chicago Cubs. Colin Cowherd discusses Ohtani’s dominance and how he will continue to transcend baseball.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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