Astros vs. Angels Prediction, Odds, Picks - April 12

Data Skrive

Yordan Alvarez and the Houston Astros face the Los Angeles Angels on Saturday at Daikin Park. Tyler Anderson will be on the mound for Los Angeles, with first pitch at 7:10 p.m. ET. Oddsmakers list the Astros as -141 favorites on the moneyline, while giving the underdog Angels +119 moneyline odds to win. Houston is the favorite on the run line (-1.5). The over/under is 8.5 runs for the contest.

Here is everything you need to know from a betting perspective on the Astros-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Angels Game Information & Odds

When: Saturday, April 12, 2025 at 7:10 p.m. ET
Where: Daikin Park in Houston, Texas
How to watch on TV: SCHN and FDSSC

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Astros -141 +119 8.5 -122 +101 -1.5 +148 -178

Astros vs. Angels Prediction

Score Prediction: Astros 5, Angels 4
Total Prediction: Over 8.5 runs
Win Probabilities: Astros 52%, Angels 48%

Astros vs. Angels Betting Insights

The Astros have won two of the six games they’ve played as favorites this season.
Houston has played as favorites of -141 or more twice this season and lost both games.
Sportsbooks have implied with the moneyline set for this matchup that the Astros have a 58.5% chance to win.
The Angels have been chosen as underdogs in nine games this year and have walked away with the win six times (66.7%) in those games.
Los Angeles has a mark of 3-2 in contests where bookmakers favor it by +119 or worse on the moneyline.
The Angels have an implied victory probability of 45.7% according to the moneyline set by oddsmakers for this matchup.

Astros Player Insights

Jose Altuve provides the Astros with a shot of both power and average, leading the team in big flies with three and hitting at .346. He has also driven in six runs this season.
In all of Major League Baseball, Altuve ranks 28th in homers and 82nd in RBI.
Altuve takes a hitting streak of five games into this game. In his last five games he is batting .375 with two home runs, two walks and five RBI.
Jeremy Pena is batting .186 with a double, two home runs and four walks.
Among all major league hitters, Pena ranks 57th in homers and 240th in RBI.
Pena carries a two-game streak with at least one hit into this contest. During his last five outings he is hitting .250 with a double and two walks.
Alvarez has racked up a team-best eight runs batted in.
Alvarez will look to build on his two-game hitting in this matchup. In his last five games he is hitting .294 with a home run, five walks and four RBI.
Jake Meyers is hitting .276 with two doubles and four walks.
Meyers brings a five-game streak with at least one hit into this one. In his last five games he is hitting .316 with two doubles, four walks and an RBI.

Angels Player Insights

Kyren Paris has hit a team-best five home runs.
Paris’ home run total places him fourth in MLB, and he ranks 42nd in RBI.
Mike Trout has hit five home runs with 11 runs batted in, leading the team in both categories.
Trout is fourth among all hitters in MLB in homers, and 16th in RBI.
Logan O’Hoppe has a team-best batting average of .359, and paces the Angels in home runs (five).
Taylor Ward has a double, three home runs and three walks while hitting .235.