Giants vs. Brewers Prediction, Odds, Picks - April 22

Data Skrive

Matt James Chapman and the San Francisco Giants will take the field at Oracle Park against the Milwaukee Brewers and Jackson Chourio on Tuesday. The favored Giants have -136 moneyline odds to win against the underdog Brewers, who are listed at +115. San Francisco is the favorite on the run line (-1.5 with +155 odds). The over/under is 7.5 runs for the game (with -112 odds on the over and -108 odds on the under).

Check out everything you need to know from a betting perspective on the Giants-Brewers game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best moments between the Athletics and the Milwaukee Brewers.

Giants vs. Brewers Game Information & Odds

When: Tuesday, April 22, 2025 at 9:45 p.m. ET
Where: Oracle Park in San Francisco, California
How to watch on TV: NBCS-BA and FDSWIX

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Giants -136 +115 7.5 -112 -108 -1.5 +155 -187

Giants vs. Brewers Prediction

Score Prediction: Giants 5, Brewers 4
Total Prediction: Over 7.5 runs
Win Probabilities: Giants 56%, Brewers 44%

Giants vs. Brewers Betting Insights

This season, the Giants have been favored 10 times and won seven of those games.
San Francisco has a record of 4-2 when favored by -136 or more by bookmakers this season.
The Giants have a 57.6% chance to win this game based on the implied probability of the moneyline.
The Brewers have been underdogs in eight games this season and have come away with the win two times (25%) in those contests.
This season, Milwaukee has been victorious one time in six chances when named as an underdog of at least +115 or longer on the moneyline.
Oddsmakers have implied with the moneyline set for this matchup that the Brewers have a 46.5% chance of pulling out a win.

Giants Recent Betting Performance

Over the last 10 games, the Giants were named the moneyline favorite by oddsmakers just two times, and they split those games.
In their last 10 matchups (all had set totals), the Giants combined with their opponents to go over the run total seven times.
The Giants have gone 4-6-0 against the spread over their past 10 games.

Giants Recent Stats

Stat Avg/Total Record 5-5 Runs Per Game 5.4 HR 11 ERA 4.55 K/9 10.2

Giants Player Insights

The Giants best hitter so far this season is Jung Hoo Lee, who’s hitting at a team-leading .333 rate along with three homers and 14 RBI.
In all of the majors, Lee ranks 74th in homers and 33rd in RBI.
Matt James Chapman is hitting .240 with three doubles, four home runs and 21 walks.
Chapman ranks 43rd in homers in the majors, and 33rd in RBI.
Wilmer Flores has accumulated a team-high six home runs and 23 runs batted in.
Mike Yastrzemski is hitting .279 with six doubles, three home runs and 12 walks.

Brewers Recent Betting Performance

In five games over the last 10 matchups when set as underdogs by oddsmakers, the Brewers had a record of 2-3.
In their last 10 games with a total, the Brewers and their opponents have combined to hit the over two times.
The Brewers have won six of their last 10 games against the spread.

Brewers Recent Stats

Stat Avg/Total Record 5-5 Runs Per Game 4.6 HR 7 ERA 2.89 K/9 8.6

Brewers Player Insights

Jackson Chourio paces the Brewers in home runs (five) and runs batted in (19).
Among all batters in MLB, Chourio is 25th in homers and seventh in RBI.
Brice Turang is hitting .322 with a double, three home runs and five walks.
Among all major league hitters, Turang is 74th in homers and 70th in RBI.
Sal Frelick has a team-high batting average of .342.
William Jesus (Castillo) Contreras is hitting .230 with two doubles, three home runs and 13 walks.

Check out the best moments between the Athletics and the Milwaukee Brewers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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